PT  - JOURNAL ARTICLE
AU  - Munguía, Obdulia
AU  - Parrilla, Maria J.
AU  - Llabrés, Matias
TI  - The Statistical Interpretation of Accelerated Degradation Studies in Solutions
DP  - 1986 May 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 100--103
VI  - 40
IP  - 3
4099  - http://journal.pda.org/content/40/3/100.short
4100  - http://journal.pda.org/content/40/3/100.full
SO  - PDA J Pharm Sci Technol1986 May 01; 40
AB  - A statistical model is proposed to explain the accelerated stability assays that justify the Garrett method, based on the proportionality of the errors. This model permits us to assay the fitting of the experimental observations for the Arrhenius equation. An application is illustrated with the study of the accelerated stability of a solution of procaine chlorohydrate at pH 7.5, where it was found that in the temperature range of 21.5-80 °C the fitting of the Arrhenius equation was satisfactory.