RT Journal Article
SR Electronic
T1 The Statistical Interpretation of Accelerated Degradation Studies in Solutions
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 100
OP 103
VO 40
IS 3
A1 Munguía, Obdulia
A1 Parrilla, Maria J.
A1 Llabrés, Matias
YR 1986
UL http://journal.pda.org/content/40/3/100.abstract
AB A statistical model is proposed to explain the accelerated stability assays that justify the Garrett method, based on the proportionality of the errors. This model permits us to assay the fitting of the experimental observations for the Arrhenius equation. An application is illustrated with the study of the accelerated stability of a solution of procaine chlorohydrate at pH 7.5, where it was found that in the temperature range of 21.5-80 °C the fitting of the Arrhenius equation was satisfactory.