PT  - JOURNAL ARTICLE
AU  - Rosenberg, L. S.
AU  - Pelland, D. W.
AU  - Black, G. D.
AU  - Aunet, D. L.
AU  - Hostetler, C. K.
AU  - Wagenknecht, D. M.
TI  - Nonisothermal Methods for Stability Prediction
DP  - 1986 Jul 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 164--168
VI  - 40
IP  - 4
4099  - http://journal.pda.org/content/40/4/164.short
4100  - http://journal.pda.org/content/40/4/164.full
SO  - PDA J Pharm Sci Technol1986 Jul 01; 40
AB  - The application of linear-up (temperature increasing), logarithmic-up (temperature increasing), or logarithmic-down (temperature decreasing) nonisothermal temperature programs to the assessment of the stability parameters of a parenteral solution is discussed. The reproducibility and accuracy of this technique are demonstrated, using the first-order degradation of riboflavin as a model. The advantages and disadvantages of these temperature programs are compared, especially in relation to Preformulation and Formulation experimental needs. A flexible nonisothermal instrument capable of running these, or any other complex temperature program, is described.