RT Journal Article
SR Electronic
T1 Nonisothermal Methods for Stability Prediction
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 164
OP 168
VO 40
IS 4
A1 Rosenberg, L. S.
A1 Pelland, D. W.
A1 Black, G. D.
A1 Aunet, D. L.
A1 Hostetler, C. K.
A1 Wagenknecht, D. M.
YR 1986
UL http://journal.pda.org/content/40/4/164.abstract
AB The application of linear-up (temperature increasing), logarithmic-up (temperature increasing), or logarithmic-down (temperature decreasing) nonisothermal temperature programs to the assessment of the stability parameters of a parenteral solution is discussed. The reproducibility and accuracy of this technique are demonstrated, using the first-order degradation of riboflavin as a model. The advantages and disadvantages of these temperature programs are compared, especially in relation to Preformulation and Formulation experimental needs. A flexible nonisothermal instrument capable of running these, or any other complex temperature program, is described.