PT  - JOURNAL ARTICLE
AU  - Preston, Wendy A.
TI  - A Device for Coring Tendency Determinations in Rubber Closures
DP  - 1986 Sep 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 207--211
VI  - 40
IP  - 5
4099  - http://journal.pda.org/content/40/5/207.short
4100  - http://journal.pda.org/content/40/5/207.full
SO  - PDA J Pharm Sci Technol1986 Sep 01; 40
AB  - An important decision in the development of a parenteral product is the selection of a suitable rubber closure. The test for relative coring tendency is generally included as part of the selection process. The strengths and weaknesses of coring test methods are reviewed and a device is presented which is designed to eliminate operator influence from the test, resulting in less subjectivity and more reproducible results. Closures with a relatively high coring tendency were used to study the influence of various machine operation factors on the coring percentage. Different operators performed the test manually to show operator-to-operator effects and to compare their results to results with the device.