RT Journal Article SR Electronic T1 A Device for Coring Tendency Determinations in Rubber Closures JF PDA Journal of Pharmaceutical Science and Technology JO PDA J Pharm Sci Technol FD Parenteral Drug Association (PDA) SP 207 OP 211 VO 40 IS 5 A1 Wendy A. Preston YR 1986 UL http://journal.pda.org/content/40/5/207.abstract AB An important decision in the development of a parenteral product is the selection of a suitable rubber closure. The test for relative coring tendency is generally included as part of the selection process. The strengths and weaknesses of coring test methods are reviewed and a device is presented which is designed to eliminate operator influence from the test, resulting in less subjectivity and more reproducible results. Closures with a relatively high coring tendency were used to study the influence of various machine operation factors on the coring percentage. Different operators performed the test manually to show operator-to-operator effects and to compare their results to results with the device.