PT  - JOURNAL ARTICLE
AU  - Mosier, Larry D.
AU  - Bosworth, Mark E.
AU  - Jurgens, Raymond W.
AU  - Mohl, Michael H.
AU  - Rizzolo, Robert R.
TI  - The Effects of pH. Time, Temperature, and Autoclaving on E. coli Endotoxin in Selected Parenteral Solutions
DP  - 1987 Jan 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 21--25
VI  - 41
IP  - 1
4099  - http://journal.pda.org/content/41/1/21.short
4100  - http://journal.pda.org/content/41/1/21.full
SO  - PDA J Pharm Sci Technol1987 Jan 01; 41
AB  - Endotoxin-spiked experimental lots of an iodinated nonionic x-ray contrast solution and a citrated saline solution were studied to determine the effectiveness of heating and pH on reduction of endotoxin levels. Inactivation of the Escherichia coli endotoxins in both 50 mM citrate saline and the nonionic contrast solution was accomplished when the medium was heated (80–90 °C) at pH = 3 or when it was autoclaved (121 °C) at neutral pH.