RT Journal Article
SR Electronic
T1 The Effects of pH. Time, Temperature, and Autoclaving on E. coli Endotoxin in Selected Parenteral Solutions
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 21
OP 25
VO 41
IS 1
A1 Mosier, Larry D.
A1 Bosworth, Mark E.
A1 Jurgens, Raymond W.
A1 Mohl, Michael H.
A1 Rizzolo, Robert R.
YR 1987
UL http://journal.pda.org/content/41/1/21.abstract
AB Endotoxin-spiked experimental lots of an iodinated nonionic x-ray contrast solution and a citrated saline solution were studied to determine the effectiveness of heating and pH on reduction of endotoxin levels. Inactivation of the Escherichia coli endotoxins in both 50 mM citrate saline and the nonionic contrast solution was accomplished when the medium was heated (80–90 °C) at pH = 3 or when it was autoclaved (121 °C) at neutral pH.