PT  - JOURNAL ARTICLE
AU  - Tarr, Bryan D.
AU  - Yalkowsky, Samuel H.
TI  - A New Parenteral Vehicle for the Administration of Some Poorly Water Soluble Anti-Cancer Drugs
DP  - 1987 Jan 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 31--33
VI  - 41
IP  - 1
4099  - http://journal.pda.org/content/41/1/31.short
4100  - http://journal.pda.org/content/41/1/31.full
SO  - PDA J Pharm Sci Technol1987 Jan 01; 41
AB  - A new parenteral vehicle was developed for three poorly water soluble anti-cancer drugs using pluronic L64. A ternary cosolvent system containing pluronic L64 (60%), ethanol (30%), and polysorbate 80 (10%) was formulated. All three drugs tested were stable in this vehicle. Methods of administration usually involve a simple dilution of one part formulation with 2 parts water. The water-diluted formulation of the three drugs studied is physically stable for three days prior to crystallization.