RT Journal Article
SR Electronic
T1 A New Parenteral Vehicle for the Administration of Some Poorly Water Soluble Anti-Cancer Drugs
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 31
OP 33
VO 41
IS 1
A1 Tarr, Bryan D.
A1 Yalkowsky, Samuel H.
YR 1987
UL http://journal.pda.org/content/41/1/31.abstract
AB A new parenteral vehicle was developed for three poorly water soluble anti-cancer drugs using pluronic L64. A ternary cosolvent system containing pluronic L64 (60%), ethanol (30%), and polysorbate 80 (10%) was formulated. All three drugs tested were stable in this vehicle. Methods of administration usually involve a simple dilution of one part formulation with 2 parts water. The water-diluted formulation of the three drugs studied is physically stable for three days prior to crystallization.