PT - JOURNAL ARTICLE AU - Preston, Wendy A. AU - Baldoni, John AU - Haeger, Bruce E. AU - Simmons, Stephen P. AU - Paul, David B. TI - Residue in Vials after Lyophilization DP - 1987 Jan 01 TA - PDA Journal of Pharmaceutical Science and Technology PG - 40--41 VI - 41 IP - 1 4099 - http://journal.pda.org/content/41/1/40.short 4100 - http://journal.pda.org/content/41/1/40.full SO - PDA J Pharm Sci Technol1987 Jan 01; 41 AB - A fluffy white residue was observed in vials that were filled with Water for Injection and lyophilized. The residue was identified by spectroscopy and wet chemical determinations to consist of sodium bicarbonate and silicone oil. An explanation is given for the source of these substances.