RT Journal Article
SR Electronic
T1 Residue in Vials after Lyophilization
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 40
OP 41
VO 41
IS 1
A1 Preston, Wendy A.
A1 Baldoni, John
A1 Haeger, Bruce E.
A1 Simmons, Stephen P.
A1 Paul, David B.
YR 1987
UL http://journal.pda.org/content/41/1/40.abstract
AB A fluffy white residue was observed in vials that were filled with Water for Injection and lyophilized. The residue was identified by spectroscopy and wet chemical determinations to consist of sodium bicarbonate and silicone oil. An explanation is given for the source of these substances.