PT  - JOURNAL ARTICLE
AU  - Myers, Ted
AU  - Kasica, Ted
AU  - Chrai, Suggy
TI  - Approaches to Cycle Development for Clean-in-PIace Processes
DP  - 1987 Jan 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 9--15
VI  - 41
IP  - 1
4099  - http://journal.pda.org/content/41/1/9.short
4100  - http://journal.pda.org/content/41/1/9.full
SO  - PDA J Pharm Sci Technol1987 Jan 01; 41
AB  - A process is described for the in-place automated cleaning of manufacturing and hold tanks. The process evaluations conducted during cycle development are described. A qualified cycle is recommended. This cycle is comprised of a 5-min chlorinated water rinse, a 3-min air purge, a 15-min detergent wash (recirculated) followed by a 12-min detergent wash, a 3-min air purge, a 15-min WFI rinse, a 3-min air purge, a 15-min WFI rinse, and a 3-min air purge. The article describes the various factors that play a role in developing a clean-in-place process.