PT  - JOURNAL ARTICLE
AU  - Mchalsky, Michael L.
AU  - Rabinow, Barrett E.
AU  - Ericson, Scott P.
AU  - Weltzer, Oseph A.
AU  - Ayd, Sharon W.
TI  - Reduction of Aluminum Levels in Dialysis Fluids Through the Development and Use of Accurate and Sensitive Analytical Methodology
DP  - 1987 Mar 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 67--75
VI  - 41
IP  - 2
4099  - http://journal.pda.org/content/41/2/67.short
4100  - http://journal.pda.org/content/41/2/67.full
SO  - PDA J Pharm Sci Technol1987 Mar 01; 41
AB  - Various analytical methods of determining the aluminum content of CAPD (continuous ambulatory peritoneal dialysis) solutions and associated raw materials were developed and compared. The methods include two graphite furnace atomic absorption procedures and an aluminum-lumogallion fluorescence technique that can quantitate aluminum in CAPD solution at, and in some cases below, the 1-μg/liter level with good accuracy and precision. These methods were then used to examine the possible contributions to aluminum content from all aspects of the production of CAPD solutions at Travenol Laboratories, Inc. The major source of aluminum to the low, but measurable, levels in CAPD solutions was lactic acid. With the use of USP grade or equivalent ingredients, especially a low-aluminum-content lactic acid, these solutions can be prepared with aluminum levels below 10 μg/liter.