RT Journal Article
SR Electronic
T1 Sterile Filtration Under Conditions of High Pressure and Bacterial Challenge Levels
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 117
OP 120
VO 41
IS 4
A1 Aicholtz, Pat
A1 Wilkins, Randy
A1 Gabler, Raymond
YR 1987
UL http://journal.pda.org/content/41/4/117.abstract
AB Experiments were performed to determine if sterilizing grade cartridge filters can retain bacteria under conditions of high challenge conditions and high pressure. In all cases the sterilizing grade filters, which passed the integrity test retained all bacteria even though the differential pressures exceeded the manufacturer’s recommended maximum continuous operating pressure. Under similar operating conditions 0.45 micron rated cartridges did not retain all bacteria.