TY - JOUR T1 - The Biocompatibility of Parenteral Vehicles— In Vitro/In Vivo Screening Comparison and the Effect of Excipients on Hemolysis JF - PDA Journal of Pharmaceutical Science and Technology JO - PDA J Pharm Sci Technol SP - 164 LP - 168 VL - 41 IS - 5 AU - Roger Cherng-Chyl Fu AU - Deborah M. Lidgate AU - John L. Whatley AU - Tim Mccullough Y1 - 1987/09/01 UR - http://journal.pda.org/content/41/5/164.abstract N2 - The hemolytic potential for a series of intravenous solutions was determined by an in vitro testing procedure; the solutions were subsequently administered intravenously to rats and evaluated for in vivo biocompatability. Each test solution contained an excipient from one or more of the following categories: nonaqueous cosolvents; complexing agents; surfactants. The test results indicate that the in vitro hemolysis values closely predict the in vivo test results. Further, a commonly used parenteral cosolvent, propylene glycol, was found to produce a large hemolytic response which can be alleviated by the addition of either a tonicifying agent or polyethylene glycol 400. These findings present useful information when formulating a parenteral vehicle utilizing an organic cosolvent. ER -