PT  - JOURNAL ARTICLE
AU  - Roger Cherng-Chyl Fu
AU  - Deborah M. Lidgate
AU  - John L. Whatley
AU  - Tim Mccullough
TI  - The Biocompatibility of Parenteral Vehicles— In Vitro/In Vivo Screening Comparison and the Effect of Excipients on Hemolysis
DP  - 1987 Sep 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 164--168
VI  - 41
IP  - 5
4099  - http://journal.pda.org/content/41/5/164.short
4100  - http://journal.pda.org/content/41/5/164.full
SO  - PDA J Pharm Sci Technol1987 Sep 01; 41
AB  - The hemolytic potential for a series of intravenous solutions was determined by an in vitro testing procedure; the solutions were subsequently administered intravenously to rats and evaluated for in vivo biocompatability. Each test solution contained an excipient from one or more of the following categories: nonaqueous cosolvents; complexing agents; surfactants. The test results indicate that the in vitro hemolysis values closely predict the in vivo test results. Further, a commonly used parenteral cosolvent, propylene glycol, was found to produce a large hemolytic response which can be alleviated by the addition of either a tonicifying agent or polyethylene glycol 400. These findings present useful information when formulating a parenteral vehicle utilizing an organic cosolvent.