RT Journal Article
SR Electronic
T1 Dynamics of Protein Recovery from Process Filtration Systems Using Microporous Membrane Filter Cartridges
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 35
OP 42
VO 46
IS 2
A1 Rajiv Datar
A1 JEROLD M. Martin
A1 Richard L. Manteuffel
YR 1992
UL http://journal.pda.org/content/46/2/35.abstract
AB The purpose of this report is to address the concern for protein concentration recovery through membrane filter cartridges at the process scale. Filtration systems consisting of pre- and/or final membrane filter cartridges were evaluated for protein concentration recovery under typical manufacturing conditions of continuous flow and high throughput volumes. Results of the study conclusively demonstrate that consideration of the protein adsorptive properties and recovery performance of cartridge filters can provide efficient bio-burden and particulate control without compromising protein yields. Understanding the dynamics of protein recovery through various prefilter and final filter cartridges can play an important role in the proper selection of a filtration system to ensure optimal life and protein yield when filtering dilute protein solutions.