PT - JOURNAL ARTICLE AU - James W. Danielson TI - Toxicity Potential of Compounds Found in Parenteral Solutions with Rubber Stoppers DP - 1992 Mar 01 TA - PDA Journal of Pharmaceutical Science and Technology PG - 43--47 VI - 46 IP - 2 4099 - http://journal.pda.org/content/46/2/43.short 4100 - http://journal.pda.org/content/46/2/43.full SO - PDA J Pharm Sci Technol1992 Mar 01; 46 AB - Leached stopper components found in parenteral solutions produced by several manufacturers were identified and quantitated. Their toxicity potential was determined by comparing the types and quantities of the leached components with known toxicity levels and / or harmful effects. Toxicity potentials for benzaldehyde, 2-butoxyethanol, cyclohexanone, ethylbenzene, 1,1,2,2-tetrachloroethane, and tetrachloroethylene are listed. Breakdown products of dextrose (furfural and 5-hydroxymethylfurfural), which may also have harmful effects, were quantitated.