RT Journal Article
SR Electronic
T1 Toxicity Potential of Compounds Found in Parenteral Solutions with Rubber Stoppers
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 43
OP 47
VO 46
IS 2
A1 Danielson, James W.
YR 1992
UL http://journal.pda.org/content/46/2/43.abstract
AB Leached stopper components found in parenteral solutions produced by several manufacturers were identified and quantitated. Their toxicity potential was determined by comparing the types and quantities of the leached components with known toxicity levels and / or harmful effects. Toxicity potentials for benzaldehyde, 2-butoxyethanol, cyclohexanone, ethylbenzene, 1,1,2,2-tetrachloroethane, and tetrachloroethylene are listed. Breakdown products of dextrose (furfural and 5-hydroxymethylfurfural), which may also have harmful effects, were quantitated.