PT  - JOURNAL ARTICLE
AU  - Jennings, Thomas A.
TI  - A Model for the Effect of Real Leaks on the Transport of Microorganisms into a Vacuum Freeze-Dryer
DP  - 1990 Jan 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 22--25
VI  - 44
IP  - 1
4099  - http://journal.pda.org/content/44/1/22.short
4100  - http://journal.pda.org/content/44/1/22.full
SO  - PDA J Pharm Sci Technol1990 Jan 01; 44
AB  - This paper proposes a model for determining the effect that real leaks, whose flow is viscous in nature, could have on the microorganism density in a vacuum freeze-dryer during a drying process. The model considers the entry of microorganisms to result from real leaks stemming from an environment containing a known bioburden. A means for determining the relationship between the rate of pressure rise of the system (ROR) and the density of microorganisms in a system, stemming from an environment of a known bioburden, is examined. The model also considers the change in the bioburden of the dryer with respect to variations in the primary and secondary drying processes.