PT  - JOURNAL ARTICLE
AU  - Wood, Ray W.
AU  - Mulsk, Michael J.
AU  - Kuu, Wei-Youth
TI  - Prediction of Water Vapor Transport Rates Across Polyvinylchloride Packaging Systems Using a Novel Radiotracer Method
DP  - 1990 Sep 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 278--281
VI  - 44
IP  - 5
4099  - http://journal.pda.org/content/44/5/278.short
4100  - http://journal.pda.org/content/44/5/278.full
SO  - PDA J Pharm Sci Technol1990 Sep 01; 44
AB  - A radiotracer method is used to study the transport properties of water vapor in polyvinylchloride (PVC), a plastic commonly used in the packaging of parenteral solutions. Water vapor transport across a PVC film appears to be Fickian in nature. Using the steady-state solution of Picks second law and the permeability coefficient of water vapor across the PVC film obtained using the described method, the predicted water vapor transport rate (WVTR) for a parenteral solution packaged in PVC is in reasonable agreement with actual WVTR as determined by weight loss under precisely controlled conditions.