PT - JOURNAL ARTICLE AU - Crane, Godfrey A. AU - Mittelman, Marc W. AU - Stephan, Margaret TI - Total Organic Carbon Measurement as a Substitute for the USP Oxidizable Substances Test DP - 1991 Jan 01 TA - PDA Journal of Pharmaceutical Science and Technology PG - 20--28 VI - 45 IP - 1 4099 - http://journal.pda.org/content/45/1/20.short 4100 - http://journal.pda.org/content/45/1/20.full SO - PDA J Pharm Sci Technol1991 Jan 01; 45 AB - The insensitivity and variability of response of the USP Oxidizable Substances Test for waters are investigated. Instrumental measurement of Total Organic Carbon (TOC) is described, and the method is compared with the Oxidizable Substances Test. Pharmaceutical factory measurements of TOC in various water systems are discussed.