RT Journal Article SR Electronic T1 Total Organic Carbon Measurement as a Substitute for the USP Oxidizable Substances Test JF PDA Journal of Pharmaceutical Science and Technology JO PDA J Pharm Sci Technol FD Parenteral Drug Association (PDA) SP 20 OP 28 VO 45 IS 1 A1 Crane, Godfrey A. A1 Mittelman, Marc W. A1 Stephan, Margaret YR 1991 UL http://journal.pda.org/content/45/1/20.abstract AB The insensitivity and variability of response of the USP Oxidizable Substances Test for waters are investigated. Instrumental measurement of Total Organic Carbon (TOC) is described, and the method is compared with the Oxidizable Substances Test. Pharmaceutical factory measurements of TOC in various water systems are discussed.