RT Journal Article
SR Electronic
T1 Effect of Certain Additives on Photodegradation of Tetracycline Hydrochloride Solutions
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 113
OP 115
VO 45
IS 2
A1 Asker, Ahmed F.
A1 Habib, Muhammad J.
YR 1991
UL http://journal.pda.org/content/45/2/113.abstract
AB The photostability of tetracycline hydrochloride solutions in the presence of selected potential stabilizers under various light sources was investigated. Reduced glutathione (GSH) demonstrated the greatest photostabilizing effect followed by p-aminobenzoic acid (PABA), ethylenediamine tetraacetic acid (EDTA) disodium salt, DL-cysteine, thiourea, sodium thiosulfate, and DL-methionine in a descending order. The photostabilizing effect of GSH was found to be dependent on its concentration, pH and buffer species of the medium, the light source, and the temperature of the solutions exposed to light.