RT Journal Article
SR Electronic
T1 Plastics, Endotoxins, and the Limulus Amebocyte Lysate Test
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 83
OP 87
VO 45
IS 2
A1 Priscilla F. Roslansky
A1 Michael E. Dawson
A1 Thomas J. Novitsky
YR 1991
UL http://journal.pda.org/content/45/2/83.abstract
AB A variety of polypropylene and polystyrene tubes have been tested for use with the Limulus amebocyte lysate (LAV) test. Polypropylene tubes tended vo be more contaminated with endotoxin than polystyrene. One brand of polypropylene tube contained a water extractable inhibitor of the LAL test. Polystyrene tubes from some manufacturers caused enhancement of the LAL test. Other polystyrene tubes were not significantly different from glass for storage of endotoxin or dilution water. Results of these studies indicate that while some tubes are well suited for use with the LAL test, others are not.