PT  - JOURNAL ARTICLE
AU  - Sally J. Seeber
AU  - Joe L. White
AU  - Stanley L. Hem
TI  - Solubilization of Aluminum-Containing Adjuvants by Constituents of Interstitial Fluid
DP  - 1991 May 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 156--159
VI  - 45
IP  - 3
4099  - http://journal.pda.org/content/45/3/156.short
4100  - http://journal.pda.org/content/45/3/156.full
SO  - PDA J Pharm Sci Technol1991 May 01; 45
AB  - The solubilization of three commercially available aluminum-containing adjuvants by citrate anion was studied. Amorphous aluminum hydroxy phosphate and boehmite were both solubilized, however, amorphous aluminum hydroxyphosphate dissolved significantly faster than boehmite. The results suggest that citrate and other α-hydroxy carboxylate anions in the interstitial fluid are able to solubilize and thereby facilitate the excretion of aluminum from aluminum-containing adjuvants which are administered by intramuscular injection. The results also suggest that the release of antigen following administration may be significantly more rapid from an amorphous aluminum hydroxyphosphate-adjuvanted vaccine in comparison to a boehmite-adjuvanted vaccine.