RT Journal Article
SR Electronic
T1 Solubilization of Aluminum-Containing Adjuvants by Constituents of Interstitial Fluid
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 156
OP 159
VO 45
IS 3
A1 Seeber, Sally J.
A1 White, Joe L.
A1 Hem, Stanley L.
YR 1991
UL http://journal.pda.org/content/45/3/156.abstract
AB The solubilization of three commercially available aluminum-containing adjuvants by citrate anion was studied. Amorphous aluminum hydroxy phosphate and boehmite were both solubilized, however, amorphous aluminum hydroxyphosphate dissolved significantly faster than boehmite. The results suggest that citrate and other α-hydroxy carboxylate anions in the interstitial fluid are able to solubilize and thereby facilitate the excretion of aluminum from aluminum-containing adjuvants which are administered by intramuscular injection. The results also suggest that the release of antigen following administration may be significantly more rapid from an amorphous aluminum hydroxyphosphate-adjuvanted vaccine in comparison to a boehmite-adjuvanted vaccine.