PT  - JOURNAL ARTICLE
AU  - Gary H. Ward
AU  - Skysamuel H. Yalkow
TI  - The Role of the Effective Concentration in Interpreting Hemolysis Data
DP  - 1992 Sep 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 161--162
VI  - 46
IP  - 5
4099  - http://journal.pda.org/content/46/5/161.short
4100  - http://journal.pda.org/content/46/5/161.full
SO  - PDA J Pharm Sci Technol1992 Sep 01; 46
AB  - Problems inherent in traditional methods of determining the hemolytic activity of parenteral compounds are discussed. Data taken from a study which closely models the conditions present for an intravenous injection are re-examined. An equation is given which combines several variables into a single parameter, the effective concentration. A strong relationship is found between the effective concentration of the compound of interest and the hemolysis produced.