PT  - JOURNAL ARTICLE
AU  - Ward, Gary H.
AU  - Samuel H., Yalkowsky
TI  - Studies in Phlebitis IV: Injection Rate and Amiodarone-lnduced Phlebitis
DP  - 1993 Jan 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 40--43
VI  - 47
IP  - 1
4099  - http://journal.pda.org/content/47/1/40.short
4100  - http://journal.pda.org/content/47/1/40.full
SO  - PDA J Pharm Sci Technol1993 Jan 01; 47
AB  - Using a rabbit ear model and techniques developed previously (1) the relationship between injection rate and injection phlebitis is investigated for amiodarone HCl and its vehicle. A number of injection rates ranging from 0.02 to 3.0 ml/min are studied using this model. Thermal measurements and visual evaluations are used for phlebitis quantitation. The severity of phlebitis is found to be dependent upon the injection rate for amiodarone HCl while the vehicle did not produce phlebitis at any rate. Strong correlations between the thermal measurements and visual evaluations are found for both amiodarone HCl and its vehicle.