RT Journal Article
SR Electronic
T1 Influence of Copper, Iron, and Zinc on the Physicochemical Properties of Parenteral Admixture
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 199
OP 204
VO 47
IS 5
A1 B. Harraki
A1 P. Guiraud
A1 M. H. Rochat
A1 M. Fussellier
A1 A. Favier
YR 1993
UL http://journal.pda.org/content/47/5/199.abstract
AB A parenteral admixture composed of 25% of 20% Intralipid®, 25% of Azonutril® 25, 37.5% of 30% Glucose® and 12.5% of 50% Glucose® was supplemented with copper, iron and zinc in the organic (gluconate) or inorganic (chloride) form at the following usual final concentrations: copper 0.24 mg/L, iron 0.50 mg/L, zinc 2.00 mg/L. The mixture was stored at 4°C and at 25°C for 24, 48, and 72 hours, and for one week. Determination of the pH indicated good stability of the mixture containing the trace elements in the gluconate form. A significant decrease in the pH of the mixture containing the trace elements as chlorides was noted after one week of storage at both temperatures. Particle size analysis revealed no significant variations between the two formulations after one week of storage. Flocculation kinetics confirmed the results obtained with the other two methods used to determine physicochemical stability. In addition, the kinetics indicated that the possibilities of coalescence processes are highly reduced in all cases. It may be concluded that the two type of mixtures remain stable for Seven days at 4°C and 25°C. However, mixtures containing trace elements in gluconate form should be chosen in cases of longer storage.