TY - JOUR T1 - An Approach to the Determination of Endotoxin in Anesthetics and Antibiotics: Use of an Ultrafiltration System and Enzymatic LAL Reaction JF - PDA Journal of Pharmaceutical Science and Technology JO - PDA J Pharm Sci Technol SP - 205 LP - 210 VL - 47 IS - 5 AU - Honorato Justicia AU - Modesto Ibanez Y1 - 1993/09/01 UR - http://journal.pda.org/content/47/5/205.abstract N2 - An ultrafiltration system is used to obtain an endotoxin-free buffer for the LAL test. The procedure is combined with a kinetic LAL reaction of high sensitivity. This approach allows for the easy determination of endotoxin levels in parenterals with LAL-interfering substances, reducing the maximum valid dilution necessary for use in product development. ER -