PT  - JOURNAL ARTICLE
AU  - John D. Ludwig
AU  - Peter D. Nolan
AU  - Craig W. Davis
TI  - Automated Method for Determining Instron Residual Seal Force of Glass Vial/Rubber Closure Systems
DP  - 1993 Sep 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 211--253
VI  - 47
IP  - 5
4099  - http://journal.pda.org/content/47/5/211.short
4100  - http://journal.pda.org/content/47/5/211.full
SO  - PDA J Pharm Sci Technol1993 Sep 01; 47
AB  - Instron Residual Seal Force (IRSF) of glass vial/rubber closure systems was determined using an Instron 4501 Materials Testing System. Computer programs were written to process raw data and calculate IRSF values. Preliminary experiments indicated both the appearance of the stress-deformation curves and precision of the derived IRSF values were dependent on the internal dimensions and top surface geometry of the cap anvil. Therefore, a series of five cap anvils varying in shape and dimensions were machined to optimize performance and precision. Vials capped with West 4416/50 PURCOA T® button closures or Helvoet compound 6207 lyophilization closures were tested with each cap anvil. Cap anvils with spherical top surfaces and narrow internal dimensions produced more precise results and more uniform stress-deformation curves than cap anvils with flat top surfaces and wider internal dimensions.