PT  - JOURNAL ARTICLE
AU  - Foroni, Luc A.
AU  - Rochat, Marie H.
AU  - Trouiller, Patrice
AU  - Calop, Jean Y.
TI  - Particle Contamination in a Ternary Nutritional Admixture
DP  - 1993 Nov 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 311--314
VI  - 47
IP  - 6
4099  - http://journal.pda.org/content/47/6/311.short
4100  - http://journal.pda.org/content/47/6/311.full
SO  - PDA J Pharm Sci Technol1993 Nov 01; 47
AB  - During total parenteral nutrition, the intravenous infusion of large volumes over a prolonged period of time appears to involve risks of particle contamination for the patients. The aim of this work is to number, measure, and characterize inert particles in a standard ternary mixture prepared by sterile transfer technique. The distribution of particles is studied in each component of the admixture and in the final preparation using two different methods: the Coulter counter and an optical microscopic numbering after filtration. The nature and the origin of particles are determined by the use of scanning electron microscopy (SEM) coupled with a photon X spectrometer.