RT Journal Article
SR Electronic
T1 Particle Contamination in a Ternary Nutritional Admixture
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 311
OP 314
VO 47
IS 6
A1 Foroni, Luc A.
A1 Rochat, Marie H.
A1 Trouiller, Patrice
A1 Calop, Jean Y.
YR 1993
UL http://journal.pda.org/content/47/6/311.abstract
AB During total parenteral nutrition, the intravenous infusion of large volumes over a prolonged period of time appears to involve risks of particle contamination for the patients. The aim of this work is to number, measure, and characterize inert particles in a standard ternary mixture prepared by sterile transfer technique. The distribution of particles is studied in each component of the admixture and in the final preparation using two different methods: the Coulter counter and an optical microscopic numbering after filtration. The nature and the origin of particles are determined by the use of scanning electron microscopy (SEM) coupled with a photon X spectrometer.