PT  - JOURNAL ARTICLE
AU  - Terezinha J. A. Pinto
AU  - Takako Saito
AU  - Mario Iossif
TI  - Ethylene Oxide Sterilization: III—Influence of Carrier Nature in a Biological Monitor Performance
DP  - 1994 May 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 155--158
VI  - 48
IP  - 3
4099  - http://journal.pda.org/content/48/3/155.short
4100  - http://journal.pda.org/content/48/3/155.full
SO  - PDA J Pharm Sci Technol1994 May 01; 48
AB  - The ethylene oxide sterilization process control should take into account several parameters, so that only the biological monitor can integrate in all of them, presenting a biological challenge similar to the product under sterilization conditions. The authors evaluated spore resistance on several different carriers: paper, aluminum foil and plastic. The influence was studied through the challenge of sub-lethal cycles, followed by the lethality study and the D-value calculation. There was a significant statistical difference in spore resistance between paper and plastic carriers.