RT Journal Article
SR Electronic
T1 Studies on the Scale-Up of Microfiltration Membrane Devices
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 184
OP 188
VO 48
IS 4
A1 Brose, Daniel J.
A1 Cates, Steve
A1 Hutchison, Fred A.
YR 1994
UL http://journal.pda.org/content/48/4/184.abstract
AB This paper addresses the prediction and modeling of fouling in microfiltration (MF) membrane devices during the filtration of biological solutions. The membrane-fouling model described can be used by bioengineers to characterize a solution's filterability when using a specific microfiltration product line. This allows bioengineers to predict the scale up of filtration from laboratory through clinical production to full marketing production. The model used to correlate filtration results contains two parameters (initial flux and membrane plugging constant) that must be determined experimentally. Once these parameters are known, it is possible to predict the performance (fouling and throughput) of larger membrane devices as a function of operating pressure, processing time, and membrane area. This allows users of MF devices to perform laboratory tests of their solution at relatively small scale, and based on these tests determine the performance of larger-scale MF devices for filtration of the same solution.