RT Journal Article
SR Electronic
T1 Drug Delivery Systems for the Future
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 247
OP 254
VO 48
IS 5
A1 Hnatyszyn, H. James
A1 Kossovsky, Nir
A1 Gelman, Andrew
A1 Sponsler, Edward
YR 1994
UL http://journal.pda.org/content/48/5/247.abstract
AB Parenteral drug delivery systems have the potential to make drugs both safer and more effective. While research in this field has been active for over 30 years, the current fiscal constraints of health care delivery add a greater degree of urgency to finding a working system. The three competing technologies currently under development include prodrug or zymogen-like systems, simple soluble macromolecular systems, and complex particulate multicomponent systems. In this review, the advantages, disadvantages, and areas for further development of these three basic technology systems are compared and contrasted; the biophysical constraints are considered; and a model solution system using surface modified nanocrystalline ceramics is described.