RT Journal Article
SR Electronic
T1 Prediction of Lyophile Collapse Temperature by Dielectric Analysis
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 318
OP 329
VO 48
IS 6
A1 Morris, Kenneth R.
A1 Evans, Sean A.
A1 Mackenzie, Alan P.
A1 Scheule, Donald
A1 Lordi, Nicholas G.
YR 1994
UL http://journal.pda.org/content/48/6/318.abstract
AB A new method for predicting lyophile collapse temperatures based upon dielectric analysis (DEA) of frozen two component systems is presented. The method, called the take off frequency model (TOF), relies both on the inherent ability of DEA to detect molecular motion and on the abrupt change in viscosity experienced by a frozen sample undergoing a glass-liquid transition. Collapse temperatures for binary glass forming systems (an antibiotic, sucrose, trehalose, or sorbitol, with water) were in good agreement with the values reported in the literature. DEA was easily able to detect glass transitions poorly defined by differential scanning calorimetry (DSC). Conservative lyophilization cycles for simple systems can be quickly determined on the basis of the TOF model.