RT Journal Article
SR Electronic
T1 Liposomal Formulations of a Novel Antitumor Agent: Drug Loading and Optimization
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 9
OP 12
VO 49
IS 1
A1 Leo Pavliv
A1 Praveen Tyle
A1 Amanda Johnston
YR 1995
UL http://journal.pda.org/content/49/1/9.abstract
AB A lyophilized, parenteral, liposomal dosage form was developed for an insoluble novel antitumor agent. Drug loading optimization studies were conducted to achieve 100% drug loading while reaching drug concentrations up to 1.0%. The reconstituted, lyophilized product was similar in morphology, particle size, and drug concentration to the liquid product. Systemic delivery of the dosage form to mice resulted in drug plasma levels in the range considered necessary for antitumor activity.