PT  - JOURNAL ARTICLE
AU  - Kagkadis, K. A.
AU  - Rekkas, D. M.
AU  - Dallas, P. P.
AU  - Choulis, N. H.
TI  - A Freeze-Dried Injectable Form of Ibuprofen: Development and Optimisation Using Response Surface Methodology
DP  - 1996 Sep 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 317--323
VI  - 50
IP  - 5
4099  - http://journal.pda.org/content/50/5/317.short
4100  - http://journal.pda.org/content/50/5/317.full
SO  - PDA J Pharm Sci Technol1996 Sep 01; 50
AB  - In this study a complex of Ibuprofen and b-Hydroxypropylcyclodextrin was prepared employing a freeze drying method. The production parameters and the final specifications of this product were optimized by using response surface methodology. The results show that the freeze dried complex meets the requirements for solubility to be considered as a possible injectable form.