RT Journal Article
SR Electronic
T1 A Freeze-Dried Injectable Form of Ibuprofen: Development and Optimisation Using Response Surface Methodology
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 317
OP 323
VO 50
IS 5
A1 Kagkadis, K. A.
A1 Rekkas, D. M.
A1 Dallas, P. P.
A1 Choulis, N. H.
YR 1996
UL http://journal.pda.org/content/50/5/317.abstract
AB In this study a complex of Ibuprofen and b-Hydroxypropylcyclodextrin was prepared employing a freeze drying method. The production parameters and the final specifications of this product were optimized by using response surface methodology. The results show that the freeze dried complex meets the requirements for solubility to be considered as a possible injectable form.