PT - JOURNAL ARTICLE AU - Kristina I. Duner TI - The Importance of the Quality of Water in Limulus Amebocyte Lysate Tests DP - 1995 May 01 TA - PDA Journal of Pharmaceutical Science and Technology PG - 119--121 VI - 49 IP - 3 4099 - http://journal.pda.org/content/49/3/119.short 4100 - http://journal.pda.org/content/49/3/119.full SO - PDA J Pharm Sci Technol1995 May 01; 49 AB - Commercial pharmaceutical waters were evaluated regarding their interference in the chromogenic Limulus Amebocyte Lysate (LAL) test. Two of the four tested waters strongly inhibited the U.S. Reference Standard Endotoxin, while a Control Standard Endotoxin was less affected. The inhibitory effect could be mimiced by adding trace amounts of certain metal ions to a non-interfering water. In conclusion, the water used in the LAL test must be chosen with great care.