PT  - JOURNAL ARTICLE
AU  - Qi, Hong
AU  - Heller, Debra L.
TI  - Stability and Stabilization of Insulinotropin in a Dextran Formulation
DP  - 1995 Nov 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 289--293
VI  - 49
IP  - 6
4099  - http://journal.pda.org/content/49/6/289.short
4100  - http://journal.pda.org/content/49/6/289.full
SO  - PDA J Pharm Sci Technol1995 Nov 01; 49
AB  - The stability of insulinotropin in a formulation containing 23% dextran-75 is studied. The effects of temperature, excipients, dextran concentration, and drug concentration on the stability of insulinotropin are examined. The tryptophan residue is identified as the primary degradation site in the insulinotropin molecule by LC-MS. Different antioxidants are used to stabilize the peptide. The combination of cysteine and EDTA is found to be most effective in stabilizing insulinotropin in the dextran formulation.