RT Journal Article
SR Electronic
T1 Stability and Stabilization of Insulinotropin in a Dextran Formulation
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 289
OP 293
VO 49
IS 6
A1 Qi, Hong
A1 Heller, Debra L.
YR 1995
UL http://journal.pda.org/content/49/6/289.abstract
AB The stability of insulinotropin in a formulation containing 23% dextran-75 is studied. The effects of temperature, excipients, dextran concentration, and drug concentration on the stability of insulinotropin are examined. The tryptophan residue is identified as the primary degradation site in the insulinotropin molecule by LC-MS. Different antioxidants are used to stabilize the peptide. The combination of cysteine and EDTA is found to be most effective in stabilizing insulinotropin in the dextran formulation.