@article {Brittain35, author = {Harry G. Brittain and Linda Lafferty and Petranna Bousserski and Glenn Diegnan and Ralph Lessor and Camille Small and Satish Pejaver}, title = {Stability of Revex{\texttrademark}, Nalmefene Hydrochloride Injection}, volume = {50}, number = {1}, pages = {35--39}, year = {1996}, publisher = {Parenteral Drug Association (PDA)}, abstract = {The stability of Revex{\texttrademark}, nalmefene hydrochloride injection, has been studied at several temperatures for periods up to 36 months. The data were obtained using a HPLC method for the potency determination, and for the level of the sole degradation product (2,2'-bisnalmefene). These methods were found to be characterized by excellent precision, linearity, and accuracy over the analyte concentration ranges established. The stability data were found to be interpretable using first-order kinetics, and essentially comparable rate constants were calculated for both the potency loss and the formation of 2,2' -bisnalmefene. Applying the Arrhenius equation to these data, a rate constant of 0.000441 month{\textendash}1 was deduced for the reactions taking place at 25{\textdegree}C. This low value is consistent with the excellent stability exhibited by the product, and amply justifies its shelf life.}, issn = {0006-3363}, URL = {https://journal.pda.org/content/50/1/35}, eprint = {https://journal.pda.org/content/50/1/35.full.pdf}, journal = {PDA Journal of Pharmaceutical Science and Technology} }