PT  - JOURNAL ARTICLE
AU  - Asker, Ahmed F.
AU  - Ferdous, Abu J.
TI  - Photodegradation of Furosemide Solutions
DP  - 1996 May 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 158--162
VI  - 50
IP  - 3
4099  - http://journal.pda.org/content/50/3/158.short
4100  - http://journal.pda.org/content/50/3/158.full
SO  - PDA J Pharm Sci Technol1996 May 01; 50
AB  - Photodegradation of furosemide was studied under the influence of fluorescent and UV lights. Photodecomposition of furosemide solutions appeared to follow first-order kinetics. The compound was found to be most stable at an optimum pH of 7. Long-wave UV light caused the fastest rate of degradation of furosemide. Glutathione, thiourea, EDTA, sodium thiosulfate, sodium metabisulfite, glycine, sodium benzoate and uric acid were found to be ineffective as photoprotective agents. Increase in ionic strength did not cause any change in the degradation rate constant. Amber glass vials and transparent glass vials covered with aluminum foil offered complete protection against fluorescent light. A vehicle consisting of a mixture of 50% (v/v) propylene glycol in phosphate buffer offered slight photoprotection.