PT  - JOURNAL ARTICLE
AU  - Brose, Daniel
AU  - Dosmar, Michael
AU  - Cates, Steve
AU  - Hutchison, Fred
TI  - Studies on the Scale-Up of Crossflow Filtration Devices
DP  - 1996 Jul 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 252--260
VI  - 50
IP  - 4
4099  - http://journal.pda.org/content/50/4/252.short
4100  - http://journal.pda.org/content/50/4/252.full
SO  - PDA J Pharm Sci Technol1996 Jul 01; 50
AB  - This paper descrribes a new method that makes it possible to predict the performance of crossflow ultrafiltration and microfiltration when scaling up from small laboratory scale to process-scale systems. Using this method, one characterizes a solution's filtration properties with a specific ultrafiltration or microfiltration membrane in a laboratory-scale crossflow device. Based on experimental results at this scale, one can accurately predict scale-up performance from laboratory through clinical production to full marketing production. Given the need for biopharmaceutical engineers to rapidly predict the size and cost of full-scale filtration processes once products receive regulatory approval, this method will find wide use in the pharmaceutical industry.