PT  - JOURNAL ARTICLE
AU  - Der Veen, J. Van
AU  - Verbrugge, Ph.
AU  - Van De Vaart, F. J.
AU  - Boom, F. A.
TI  - Particulate Matter Determination in LVPs Produced in Dutch Hospital Pharmacies, Part 1: Particle-Counting Accuracy
DP  - 1997 Mar 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 81--88
VI  - 51
IP  - 2
4099  - http://journal.pda.org/content/51/2/81.short
4100  - http://journal.pda.org/content/51/2/81.full
SO  - PDA J Pharm Sci Technol1997 Mar 01; 51
AB  - Reproducible particle counting using the light-obscuration technique is often troublesome because no absolute standard is available. Therefore, at the Laboratory of Dutch Pharmacists the “calibration-in-time” method was developed. This method enables checking of the amount of particles counted from a diluted latex suspension as a function of time. A particularity of the method is the one-step dilution procedure. The calibration-in-time method is compared with the particle-counting accuracy test according to the USP <788>. Advantages and disadvantages of both methods are discussed.