RT Journal Article
SR Electronic
T1 Particulate Matter Determination in LVPs Produced in Dutch Hospital Pharmacies, Part 1: Particle-Counting Accuracy
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 81
OP 88
VO 51
IS 2
A1 Der Veen, J. Van
A1 Verbrugge, Ph.
A1 Van De Vaart, F. J.
A1 Boom, F. A.
YR 1997
UL http://journal.pda.org/content/51/2/81.abstract
AB Reproducible particle counting using the light-obscuration technique is often troublesome because no absolute standard is available. Therefore, at the Laboratory of Dutch Pharmacists the “calibration-in-time” method was developed. This method enables checking of the amount of particles counted from a diluted latex suspension as a function of time. A particularity of the method is the one-step dilution procedure. The calibration-in-time method is compared with the particle-counting accuracy test according to the USP <788>. Advantages and disadvantages of both methods are discussed.